Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 11-09-21 14:30 | 11-09-21 14:30 | SpVgg Greuther Fürth | VfL Wolfsburgo | 0:2 | 6 - 6 - 3 |
| 11-09-21 14:30 | 11-09-21 14:30 | 1899 Hoffenheim | FSV Mainz 05 | 0:2 | 3 - 6 - 6 |
| 11-09-21 14:30 | 11-09-21 14:30 | SC Friburgo | 1. FC Colónia | 1:1 | 4 - 4 - 6 |
| 11-09-21 14:30 | 11-09-21 14:30 | 1. FC Union Berlim | FC Augsburg | 0:0 | 3 - 6 - 6 |
| 11-09-21 14:30 | 11-09-21 14:30 | Bayer 04 Leverkusen | Borussia Dortmund | 3:4 | 4 - 6 - 4 |
| 11-09-21 17:30 | 11-09-21 17:30 | RB Leipzig | FC Bayern Munique | 1:4 | 6 - 5 - 3 |
| 12-09-21 14:30 | 12-09-21 14:30 | Eintracht Frankfurt | VfB Estugarda | 1:1 | 3 - 6 - 6 |
| 12-09-21 16:30 | 12-09-21 16:30 | VfL Bochum | Hertha BSC Berlim | 1:3 | 4 - 4 - 6 |
| 12-09-21 18:30 | 12-09-21 18:30 | Bor. Mönchengladbach | Arminia Bielefeld | 3:1 | 3 - 6 - 6 |