Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 22-04-22 19:30 | 22-04-22 19:30 | VfL Wolfsburgo | FSV Mainz 05 | 5:0 | 3 - 6 - 6 |
| 23-04-22 14:30 | 23-04-22 14:30 | RB Leipzig | 1. FC Union Berlim | 1:2 | 3 - 6 - 6 |
| 23-04-22 14:30 | 23-04-22 14:30 | SpVgg Greuther Fürth | Bayer 04 Leverkusen | 1:4 | 6 - 6 - 3 |
| 23-04-22 14:30 | 23-04-22 14:30 | 1. FC Colónia | Arminia Bielefeld | 3:1 | 3 - 6 - 6 |
| 23-04-22 14:30 | 23-04-22 14:30 | SC Friburgo | Bor. Mönchengladbach | 3:3 | 3 - 5 - 6 |
| 23-04-22 14:30 | 23-04-22 14:30 | Eintracht Frankfurt | 1899 Hoffenheim | 2:2 | 3 - 5 - 6 |
| 23-04-22 17:30 | 23-04-22 17:30 | FC Bayern Munique | Borussia Dortmund | 3:1 | 3 - 6 - 6 |
| 24-04-22 14:30 | 24-04-22 14:30 | VfL Bochum | FC Augsburg | 0:2 | 3 - 4 - 6 |
| 24-04-22 16:30 | 24-04-22 16:30 | Hertha BSC Berlim | VfB Estugarda | 2:0 | 4 - 4 - 4 |