Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 14-01-22 19:30 | 14-01-22 19:30 | Borussia Dortmund | SC Friburgo | 5:1 | 3 - 6 - 6 |
| 15-01-22 14:30 | 15-01-22 14:30 | FSV Mainz 05 | VfL Bochum | 1:0 | 3 - 5 - 5 |
| 15-01-22 14:30 | 15-01-22 14:30 | VfB Estugarda | RB Leipzig | 0:2 | 4 - 6 - 3 |
| 15-01-22 14:30 | 15-01-22 14:30 | 1. FC Union Berlim | 1899 Hoffenheim | 2:1 | 4 - 6 - 4 |
| 15-01-22 14:30 | 15-01-22 14:30 | VfL Wolfsburgo | Hertha BSC Berlim | 0:0 | 3 - 5 - 5 |
| 15-01-22 14:30 | 15-01-22 14:30 | 1. FC Colónia | FC Bayern Munique | 0:4 | 6 - 6 - 3 |
| 15-01-22 17:30 | 15-01-22 17:30 | Bor. Mönchengladbach | Bayer 04 Leverkusen | 1:2 | 4 - 5 - 4 |
| 16-01-22 14:30 | 16-01-22 14:30 | FC Augsburg | Eintracht Frankfurt | 1:1 | 6 - 4 - 3 |
| 16-01-22 16:30 | 16-01-22 16:30 | Arminia Bielefeld | SpVgg Greuther Fürth | 2:2 | 3 - 6 - 6 |